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Goeckerman Therapy is a regimen for treatment of moderate to severe plaque psoriasis using a combination of crude coal tar and artificial ultraviolet radiation. First formulated in 1925 by American dermatologist William H. Goeckerman (1884–1954), Goeckerman therapy continues to be used due to its efficacy and safety profile.(1) Individual institutions have modified the Goeckerman regimen and developed their own protocols. Standard therapy includes use of 2%-4% crude coal tar in a petroleum base applied daily to the psoriatic plaques. The minimum period of time for tar application is 2-hours, although it has been recognized that greater periods of time produce better results. (2) The patient is then exposed to broad-band ultraviolet B (UVB) radiation, although narrow-band UVB may also be used.(3) Laboratory studies have shown that the combination of coal tar and UV light reduces epidermal DNA synthesis. (4) ==Modifications of Goeckerman therapy== In 1953, John Ingram, and English dermatologist added topical anthralin paste to his Goeckerman regimen. This is known as the Ingram method. (5) ==Cost== Recent publications have compared Goeckerman therapy with treatment with more expensive biologic agents.(6,7) Historically, Goeckerman therapy was performed as an inpatient treatment. However, today the treatment can be done with reduced cost as an outpatient. It has been stated by de Miguel et al., that an annual 3-week outpatient course of Goeckerman treatment costs $10,000-12,000 but repeat treatment may be extended to 2-years with the use of a $2,000 home UVB treatment lamp.(6). The authors state that biologic therapy costs $22,000-59,000 per year. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Goeckerman therapy」の詳細全文を読む スポンサード リンク
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